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XOCAL Natural ​

Plant Based Skin Care

CBD Health

Incredible cannabis topicals 

The Miracle Plant moringa  

An organic approach to holistic

healing, cannabis topical's and

all natural skin care. The ultimate

healthy alternative to replace

chemical rich, shelf life beauty

and skin care products.

LEARN MORE

XOCAL Natural is  Holistic Skin Care

Learn more about how Topical treatments from powerful plant based ingredients can improve your skin and overall health

Plant Based Skin Care 

January 15, 2017

We have only touched the tip of the plant world iceberg. According to current data, only 10% of 300,000 known species has been studied. Which means there are 250,000 left to go - a monumental task in a leafy world of infinite resources. Plants actually have a lot in common with humans. They breathe, grow, adapt, eat, reproduce and change according to the environment in which they grow. Scientists and researchers are continually being amazed by what they can teach us. Vitamins, antioxidants, moisturizing factors, calming or regenerative properties are just a few of what plants can offer our skin health.  Numerous plant-based active ingredients are being selected by cosmetologists for their skin-loving actions.  Plants and skin have a harmonious relationship. A relationship that researchers are optimizing in order to improve skincare products.  Try an alternative to conventional skin care, XOCAL Natural plant based holistic skin care.

Question: What do the terms 'natural,' 'organic,' 'non-toxic' and 'hypoallergenic' really mean on beauty product labels?

February 14, 2017

Natural: "Legally, this means nothing—it's a completely unregulated term and should be thought of as pure marketing.  It will generally mean that at least some natural ingredients have been used in the formula, but a product can be labeled as natural and contain up to 30 percent synthetic ingredients." Look at the label and if the product is full of ingredients born in a lab (ethyl acetate, nitrocellulose, red #11, etc.) and the only from-the-earth one you recognize is buried at the bottom, that means it's hardly natural. If all the ingredients listed are just the INCI (International Nomenclature of Cosmetic Ingredients) Latin names for things you recognize—for example: sodium cocoate is saponified coconut oil—the product is all-natural.

Organic: "The use of the word organic is actually highly regulated, and legally means a brand or ingredient has been certified by the USDA. You should see an accompanying logo that confirms this; if you don't, it means nothing and they are about to get in trouble. If you do see the logo, it means that said ingredient (or almost 100% of the ingredients in an organic product) have been grown and processed under a very strict code of cleanliness, with no pesticides or fertilizers, and absolutely no genetically modified organisms."

Non-Toxic: This is a newer designation, also mostly marketing,  When companies claim to be non-toxic, they are specifically referring to leaving out ingredients that have been linked to toxic responses in humans: neuro-disruption, hormone disruption, cancer, even death. A great, or I should say horrible, example is phthalates [found mostly in household products and shampoo and conditioner, they give products a uniform consistency and make them easier to pour.]  Here are some of the other offender ingredients to always avoid: formaldehyde (found in nail polish, hair gel and color cosmetics); petroleum (found in moisturizers and lip balms); asbestos (labeled as talc or hydrous magnesium silicate); lead acetate (found in hair dye and lipstick); coal tar (found in hair dye and anti-dandruff shampoo).

Hypoallergenic: Products labeled hypoallergenic are making the claim that they cause fewer adverse reactions than their competitors, but any product can be marked with the word.  "It holds no meaning whatsoever."

What is Holistic Skin Care?

March 15, 2017

In terms of skin care products, holistic skin care refers to topical products or internal supplements termed nutriceuticals. Topical products that claim to be holistic are characterized by containing almost 100 percent natural ingredients such as herbs, plant extracts, phytonutrients and antioxidants, and essential oils.  XOCAL Natural is holistic skin care.

As a daily nutritional supplement, CBD is enormously popular and is gaining thousands of users daily. Those who incorporate CBD usage into their daily health and wellness programs are extremely satisfied with the results and benefits. 

“The evidence is overwhelming that marijuana can relieve certain types of pain, nausea, vomiting and other symptoms caused by such illnesses as multiple sclerosis, cancer and AIDS — or by the harsh drugs sometimes used to treat them. And it can do so with remarkable safety. Indeed, marijuana is less toxic than many of the drugs that physicians prescribe every day.”

Joycelyn Elders, MD



CBD also exerts an anti-cancer effect by activating PPARs on the surface of the cell’s nucleus.

CBD Health

THE ENDOCANNABINOID SYSTEM 

Cannabis has been at the center of one of the most exciting—and underreported—developments in modern science. Research on marijuana’s effects led directly to the discovery of a hitherto unknown biochemical communication system in the human body, the Endocannabinoid System, which plays a crucial role in regulating our physiology, mood, and everyday experience.

The discovery of receptors in the brain that respond pharmacologically to cannabis—and the subsequent identification of endogenous cannabinoid compounds in our own bodies that bind to these receptors—has significantly advanced our understanding of human biology, health, and disease.

It is an established scientific fact that cannabinoids and other components of cannabis can modulate many physiological systems in the human brain and body. Cannabinoids are chemical compounds that trigger cannabinoid (and other) receptors. More than 100 cannabinoids have been identified in the marijuana plant. Of these marijuana molecules, tetrahydrocannabinol (THC) and cannabidiol (CBD) have been studied most extensively. In addition to cannabinoids produced by the plant, there are endogenous cannabinoids (such as anandamide and 2AG) that occur naturally in the mammalian brain and body, as well as synthetic cannabinoids created by pharmaceutical researchers.

Extensive preclinical research—much of it sponsored by the U.S. government—indicates that CBD has potent anti-tumoral, antioxidant, anti-spasmodic, anti-psychotic, anti-convulsive, and neuroprotective properties. CBD directly activates serotonin receptors, causing an anti-anxiety effect, as well.

CBD and THC Synergy

According to McAllister’s lab, the best results were obtained when CBD was administered along with THC. Several studies underscore the therapeutic advantages for combining CBD and THC—particularly for treating peripheral neuropathy, a painful condition associated with cancer, multiple sclerosis (MS), diabetes, arthritis, and other neurodegenerative ailments. Clinical research conducted by with GW Pharmaceuticals, a British company, has also shown that CBD is most effective as an analgesic when administered in combination with whole plant THC.

Serotonin Receptors

 At high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea and vomiting.

5-HT1A is a member of the family of 5-HT receptors, which are activated by the neurotransmitter serotonin. Found in both the central and peripheral nervous systems, 5-HT receptors trigger various intracellular cascades of chemical messages to produce either an excitatory or inhibitory response, depending on the chemical context of the message.

CBDA [Cannabidiolic acid], the raw, unheated version of CBD that is present in the cannabis plant, also has a strong affinity for the 5-HT1A receptor (even more so than CBD). Preclimical studies indicate that CBDA is a potent anti-emetic, stronger than either CBD or THC, which also have anti-nausea properties.

Vanilloid Receptors

CBD directly interacts with various ion channels to confer a therapeutic effect. CBD, for example, binds to TRPV1 receptors, which also function as ion channels. TRPV1 is known to mediate pain perception, inflammation and body temperature.

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TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” TRPV1 is one of several dozen TRP (pronounced “trip”) receptor variants or subfamilies that mediate the effects of a wide range of medicinal herbs.

Scientists also refer to TRPV1 as a “vanilloid receptor,” named after the flavorful vanilla bean. Vanilla contains eugenol, an essential oil that has antiseptic and analgesic properties; it also helps to unclog blood vessels. Historically, the vanilla bean has been used as a folk cure for headaches.

CBD binds to TRPV1, which can influence pain perception.

Capsaicin—the pungent compound in hot chili peppers—activates the TRVP1 receptor. Anandamide, the endogenous cannabinoid, is also a TRPV1 agonist.

GPR55—orphan receptors

Cannabidiol directly activates the 5-HT1A serotonin receptor and several TRPV ion channels, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55.

GPR55 has been dubbed an “orphan receptor” because scientists are still not sure if it belongs to a larger family of receptors. GPR55 is widely expressed in the brain, especially in the cerebellum. It is involved in modulating blood pressure and bone density, among other physiological processes.

GPR55 promotes osteoclast cell function, which facilitates bone reabsorption. Overactive GPR55 receptor signaling is associated with osteoporosis.

By blocking GPR55 signaling, CBD may act to decrease both bone reabsorption and cancer cell proliferation. 

PPARs - nuclear receptors

CBD also exerts an anti-cancer effect by activating PPARs [peroxisome proliferator activated receptors] that are situated on the surface of the cell’s nucleus. Activation of the receptor known as PPAR-gamma has an anti-proliferative effect as well as an ability to induce tumor regression in human lung cancer cell lines. PPAR-gamma activation degrades amyloid-beta plaque, a key molecule linked to the development of Alzheimer’s disease. This is one of the reasons why cannabidiol, a PPAR-gamma agonist, may be a useful remedy for Alzheimer’s patients.

PPAR receptors also regulate genes that are involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions. Diabetics, accordingly, may benefit from a CBD-rich treatment regimen.

CBD as a reuptake inhibitor

How does CBD, an exogenous plant compound, get inside a human cell to bind to a nuclear receptor? First it has to pass through the cell membrane by hitching a ride with a fatty acid binding protein (FABP), which chaperones various lipid molecules into the cell’s interior. These intracellular transport molecules also escort tetrahydrocannabinol (THC) and the brain’s own marijuana-like molecules, the endocannabinoids anandamide and 2AG, across the membrane to several targets within the cell. CBD and THC both modulate receptors on the surface of the nucleus, which regulate gene expression and mitochondrial activity.

CBD also exerts an anti-cancer effect by activating PPARs on the surface of the cell’s nucleus.

Cannabidiol, it turns out, has a strong affinity for three kinds of FABPs, and CBD competes with our endocannabinoids, which are fatty acids, for the same transport molecules. Once it is inside the cell, anandamide is broken down by FAAH [fatty acid amide hydrolase], a metabolic enzyme, as part of its natural molecular life cycle. But CBD interferes with this process by reducing anandamide’s access to FABP transport molecules and delaying endocannabinoid passage into the cell’s interior.

According to a team of Stony Brook University scientists, CBD functions as an anandamide reuptake and breakdown inhibitor, thereby raising endocannabinoid levels in the brain’s synapses. Enhancing endocannabinod tone via reuptake inhibition may be a key mechanism whereby CBD confers neuroprotective effects against seizures, as well as many other health benefits.

CBD’s anti-inflammatory and anti-anxiety effects are in part attributable to its inhibition of adenosine reuptake. By delaying the reuptake of this neurotransmitter, CBD boosts adenosine levels in the brain, which regulates adenosine receptor activity. A1A and A2A adenosine receptors play significant roles in cardiovascular function, regulating myocardial oxygen consumption and coronary blood flow. These receptors have broad anti-inflammatory effects throughout the body.

CBD as an allosteric modulator

CBD also functions as an allosteric receptor modulator, which means that it can either enhance or inhibit how a receptor transmits a signal by changing the shape of the receptor.

Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA-A receptor. In other words, CBD interacts with the GABA-A receptor in a way that enhances the receptor’s binding affinity for its principal endogenous agonist, gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. The sedating effects of Valium and other Benzos are mediated by GABA receptor transmission. CBD reduces anxiety by changing the shape of the GABA-A receptor in a way that amplifies the natural calming effect of GABA.

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Canadian scientists have identified CBD as a “negative allosteric modulator” of the cannabinoid CB1 receptor, which is concentrated in the brain and central nervous system. While cannabidiol doesn’t bind to the CB1 receptor directly like THC does, CBD interacts allosterically with CB1 and changes the shape of the receptor in a way that weakens CB1’s ability to bind with THC.

As a negative allosteric modulator of the CB1 receptor, CBD lowers the ceiling on THC’s psychoactivity—which is why people don’t feel as “high” when using CBD-rich cannabis compared to when they consume THC-dominant medicine. A CBD-rich product with little THC can convey therapeutic benefits without having a euphoric or dysphoric effect.

Moringa Oleifera

Easily absorbed into the skin, Moringa is a super anti-aging skincare ingredient that pledges to clear skin of acne, inflammation, reduce wrinkles, and restore health to aging skin.  XOCAL is currently working with scientists and skin care professionals to reformulate our classic skin care line and create new innovative products using Moringa.    

The miracle tree Moringa is a multipurpose that is native to parts of Africa and Asia. It is also called drumstick tree by the British and Malunggay in Philippines​

In India, it is found on the foothills of the Himalayan mountains. This plant belongs to the family Moringaceae. It derives its name from the Malayalam word, ‘Muringa’. It is a multipurpose plant and its leaves, pods, fruits, flowers, roots and bark are beneficial in one way or the other. 


The most amazing thing about moringa is that all parts of this plant including its bark, roots, leaves, flowers, seeds, sap and pods are a storehouse of nutrients and antioxidants. Thus, this plant possesses innumerable health benefits and has the capacity of curing several diseases. For this reason, it is referred to as the ‘miracle tree’ and is widely used in traditional medicine.